Injectable Decellularize

Our in vitro results indicated that DWJH/CD56+Exos significantly enhanced the biological activity of hBMSCs and effectively induced chondrogenic differentiation of hBMSCs. Additionally, our rat model results revealed that injectable DWJH/CD56+Exos effectively promoted meniscus healing and protected knee against articular cartilage degeneration.

https://tinyurl.com/mpad2n9x

Exosome Wound Healing

Mass spectrometry analysis revealed that exosomes of Wharton's jelly umbilical cord contain a large amount of alpha-2-macroglobulin, a protein which mimics the effect of acellular gelatinous Wharton's jelly exosomes on wound healing.

https://pubmed.ncbi.nlm.nih.gov/30005703/

Cartilage Repair Exosomes

In particular, let-7e-5p, which is found in WJMSC-sEVs, was shown to be a potential core molecule for promoting cartilage regeneration by regulating the levels of STAT3 and IGF1R. Our findings suggest that WJMSC-sEV-induced chondrogenesis is a promising innovative and feasible cell-free nanotherapy for OA treatment.

https://pubmed.ncbi.nlm.nih.gov/35753534/

Skin Healing Exosomes

Exosomes are being enriched in the native niche of the umbilical cord and can enhance wound healing in vivo through their cargo. Exosomes from the acellular gelatinous Wharton's jelly and the cargo protein alpha-2-macroglobulin have tremendous potential as a noncellular, off-the-shelf therapeutic modality for wound healing.

https://pubmed.ncbi.nlm.nih.gov/30005703/